Reliable tests for the detection of patulin in food


Patulin: Monitoring and analysis

Importance of monitoring patulin

Patulin is a mycotoxin mainly found in rotting apples and is produced by mold fungi of the Aspergillus and Penicillium species. While not considered a very strong toxin, patulin has demonstrated genotoxicity in studies, indicating potential mutagenic and carcinogenic effects. The presence of patulin in apple products is often used as an indicator of the quality of the apples used in food production.

Common sources and effects of patulin

Patulin contamination can occur in various apple products, including:

  • Apple juice
  • Apple sauce
  • Apple puree
  • Baby food
  • Apple cider

Regulatory compliance and consumer protection

Many countries have established restrictions on patulin levels in apple products. In November 2003, the EU set the following limit values for patulin in food:

ProductsLimit value
Fruit juice, spirits and apple cider50 ppb
Solid apple products for immediate consumption25 ppb
Baby food, apple juice and apple products for young children10 ppb

Analytical solutions for patulin detection

Detecting patulin can be challenging due to the low quantities typically present in products and the potential for interference from other components in complex matrices. Sensitivity and sample preparation are critical for accurate detection.

EASIMIP™ PATULIN employs a procedure based on molecularly imprinted polymers (MIP) technology, providing a specific, sensitive, quick, and easy method for patulin detection.

  • MIP columns: Contain a specific polymer designed to bind the target toxin.
  • Sample preparation: Involves extraction, centrifugation, filtration, and application to MIP columns. The toxins are bound in the column, washed to remove impurities, and then eluted with an MIP solvent for HPLC analysis.

This method offers improved purification and concentration of the toxin from food samples, resulting in clearer chromatograms. Additionally, crystalline patulin standards and pectinase are available for enhanced analysis.

Key benefits of patulin monitoring

  • Consumer protection: Ensures food products, especially apple-based products, are safe for consumption by detecting and quantifying patulin contamination.
  • Regulatory compliance: Helps manufacturers comply with international food safety regulations, such as those specified by the EU.
  • Quality assurance: Maintains the integrity and safety of apple products by preventing the distribution of contaminated items.
  • Advanced detection methods: Utilizes MIP technology and HPLC for accurate and sensitive detection of patulin in complex food matrices.


Monitoring patulin is essential for protecting consumer health, ensuring regulatory compliance, and maintaining the quality of apple products. By employing advanced detection methods such as MIP technology and HPLC, manufacturers can accurately identify and quantify patulin contamination, ensuring the safety of their products. This proactive approach supports robust quality control processes, upholds food safety standards, and fosters consumer trust in apple-based products.

Product portfolio

ProductDescriptionNo. of tests/amountArt. No.

Molecularly Imprinted Polymer (MIP) columns for use in conjunction with an HPLC for detection of patulin in apple juice and apple purée.

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RBRP250: 10 columns (3 ml format),
RBRP250B: 50 columns (3 ml format)
RBRP250 / RBRP250B
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